Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

Nuclear Imprisonment: Viral Strategies to Arrest Host mRNA Nuclear Export

Blog Article

Viruses possess many strategies to impair host cellular Military Spacecraft Model Kit responses to infection.Nuclear export of host messenger RNAs (mRNA) that encode antiviral factors is critical for antiviral protein production and control of viral infections.Several viruses have evolved sophisticated strategies to inhibit nuclear export of host mRNAs, including targeting mRNA export factors and nucleoporins to compromise their roles in nucleo-cytoplasmic trafficking of cellular mRNA.Here, we present a review of research focused on suppression of host mRNA nuclear export by viruses, including influenza here A virus and vesicular stomatitis virus, and the impact of this viral suppression on host antiviral responses.